Lionel Messi is expected to play as Inter Miami faces Sporting San Miguelito in Panama City, Panama at 5 p.m. ET. Here's what you need to know.

The preseason match, which kicks off at 5 p.m., is the third in the club’s Americas Tour, which also includes a game against Olimpia in Honduras next Saturday. Miami won its first two preseason games in penalty kick shootouts against Mexican team Club America and Universitario of Peru.

The Lions will head down I-4 to Tampa for the high-profile match leading up to next weekend’s MLS season opener against the Philadelphia Union.