Conversion of the 5′-triphosphate to a monophosphate now appears to be the first committed step in mRNA decay in E. coli. Figure 1: E. coli mRNA decay is activated by the conversion of the mRNA ...
In eukaryotic cells, mRNA decay is catalyzed by two major pathways, and both can be initiated by deadenylation of the polyadenylated (poly-A) tail. After decapping, 5’ to 3’ RNA degradation is ...