【导读】帕博西尼（Palbociclib）是一种CDK4/6抑制剂，在治疗HR+乳腺癌中发挥着至关重要的作用。然而，palbociclib的耐药性是一个值得进一步研究的重大问题。团队的研究发现，TMEM45A是palbociclib耐药性的潜在驱动因 ...

Although the mTOR pathway has been characterized in T cells, it has not been well described in other immune cells. In this study, Weichhart et al. investigated how mTOR activity in phagocytes ...

A patent has been granted in the US covering the use of Neurizon’s lead drug candidate NUZ-001 in neurodegenerative diseases ...

相关研究结果于2025年1月1日在线发表在Nature期刊上，论文标题为“Dysregulation of mTOR signalling is a converging mechanism in lissencephaly”。 论文共同通讯作者 ...

A study led by Dr. Peter Canoll's lab, in collaboration with researchers at Columbia University Irving Medical Center, ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

Seventeen tumor samples from 14 patients with SDH-deficient GIST underwent NGS. Mutational load was low, although three patients (21%) displayed molecular events in relapse samples leading to ...