The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

Leucine is the most important of these for muscle protein synthesis and repair. It also plays a role in regulating the mTOR pathway. “The mammalian target of rapamycin (mTOR) signalling pathway ...