They identified the mechanistic target of rapamycin complex 1 (mTORC1) pathway as a highly used system. Then the researchers developed a conditional mutant mouse model with a deleted upstream mTORC1 ...

Since currently available agents mainly inhibit mTORC1, which may lead to an increase in Akt activity through loss of the negative feedback loop mediated by the PI3K pathway, new agents and ...

However, long-term use may impair mTORC2 assembly and functioning. [9] Although less is known about this complex than mTORC1, two major functions have been attributed to mTORC2: regulation and ...