Angiotensin-converting enzyme (ACE) inhibitors are increasingly recognized as having an important role in the treatment of hypertension and/or end-organ disease. The sheer number of ACE inhibitors ...

Get Instant Summarized Text (Gist) A novel mechanism has been identified that eliminates defective transcriptional elongation enzymes during gene expression. This process involves the ARMC5 ...

While nicotine is known to enhance platelet aggregation, its effects on other platelet functions and underlying mechanisms remain unclear. Discussion: In conclusion, nicotine activates αIIbβ3 ...

This manuscript from Clayton and co-authors aims to clarify the molecular mechanism of BRAF dimer selectivity. Indeed, first generation BRAF inhibitors, targeting monomeric BRAFV600E, are ineffective ...

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, United States Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of ...

"R-loops are generally bad news, so cells have many redundant mechanisms to prevent them from forming," says Seth Darst, head of the Laboratory of Molecular Biophysics. "We discovered that RapA ...

Early studies 1 2 with the angiotensin-converting enzyme (ACE) inhibitors captopril and cilazapril demonstrated that hypertension ... Although some insight has been gained, the mechanism regarding ...

Several findings from PROGRESS warrant comment and provide perspective on the use of ACE inhibitors in a patient having suffered a stroke in the near to distant past. Single-drug therapy with ...

These mechanisms are known as “immune editing” (1 ... the left ventricular function including measurement of the left ventricular ejection fraction and strain. Beta-blockers and angiotensin-converting ...

The earlier trial also showed advantages over enalapril on hospitalisation and death rates when patients switched from an ACE inhibitor – enough to get Novartis’ drug included in treatment ...