In conclusion, hope for more efficient, individualized, and secure therapies may come from continuing research and breakthroughs in novel diabetes treatment targets. These developments are at the ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

The phosphate generally comes from adenosine triphosphate (ATP ... fluorescent biosensor allows real-time visualization of PKN kinase activity, revealing sustained activity at the plasma membrane ...

Intracellular kinases play a ubiquitous role in signaling pathways within cells. Receptor tyrosine kinases function at the beginning of a number of signal transduction cascades, whereas ...

In order to further improve therapy outcomes, innovative combinatorial treatment strategies aim to target additional immunosuppressive barriers in the tumor microenvironment such as the CD73/adenosine ...

In a recent study published in the journal Neuron, researchers at the University of Cambridge and Newcastle University, UK, examined the relationship between autophagy, aging, and neurodegeneration.