The activation of adenylate cyclase and production of cyclic adenosine monophosphate (cAMP ... however the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and ERK1/2/MAPK pathways were ...

The immune system is increasingly recognized for its role in the genesis and progression of hypertension. The adrenal gland is a major site that coordinates the stress response via the ...

Cataclysm:Dark Days Ahead and the Ultimate Cataclysm tileset is the result of contributions from volunteers under the Creative Commons Attribution ShareAlike 3.0 license. The code and content of the ...

Sustained exposure to pathological stress stimulates the heart to hypertrophy, increasing disease and mortality risk. New therapies to blunt this process include targeting enzymes below the cell ...

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Panel A summarizes the conventional model of how oncogenic RAS guanosine triphosphatases (i.e., Kirsten rat sarcoma viral oncogene homologue [KRAS], neuroblastoma RAS viral oncogene homologue ...

Objectives We have previously described the antifibrotic role of the soluble guanylate cyclase (sGC). The mode of action ... sGC stimulation blocked the phosphorylation of ERK. In vivo, sGC ...

1 Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, the Netherlands 2 Department of Experimental Internal Medicine, Academic Medical Centre, Amsterdam, the Netherlands ...