IN the midbrain of the chicken embryo a close relationship has been demonstrated between aerobic glycolysis and cell division 1, from which it can be inferred that growth is dependent on aerobic ...

Mechanistically, Acod1 suppressed osteoclast differentiation by inhibiting succinate dehydrogenase-dependent production of reactive oxygen species and Hif1α-mediated induction of aerobic glycolysis.

Cancer cells preferred aerobic glycolysis for cell proliferation. In addition, aerobic glycolysis produces metabolic precursors that are essential for rapid cell proliferation (25). As proliferation ...

Immune therapies targeting the PD-1/PD-L1 pathway have been employed in the treatment of breast cancer, which requires aerobic glycolysis to sustain breast cancer cells growth. However, whether PD-L1 ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

CDCA7 属于细胞周期调节蛋白家族，作为致癌基因，在多种肿瘤中高表达，与不良预后相关，且参与肿瘤细胞的增殖、侵袭和转移过程，但它在胰腺癌中的具体作用尚不清楚。近年来，代谢重编程在胰腺癌耐药发展中的作用受到广泛关注，其中糖酵解代谢重编程是导致化疗耐药的关键因素之一。信号转导和转录激活因子 3（STAT3）是 STAT ...

【导读】细胞分裂周期相关蛋白 7（CDCA7）在多种恶性肿瘤中发挥作用，尤其是胰腺癌（PC）。然而，其在胰腺癌中的表达模式和功能意义仍需进一步研究。2月4日，贵州医科大学研究团队在期刊《Cell ...

However, when the researchers blocked an earlier step in glycolysis, the enzyme glucose-6-phosphate isomerase, this had no effect on the growth of the cancer cells.

Glycolysis signature was upregulated along neutrophil transition trajectory, and TAN-1 was featured with hyperactivated glycolytic activity. The glycolytic switch of TANs was validated by integrative ...

RNA-seq and MS analyses indicated that L-arginine switched glycolysis to oxidative phosphorylation in inflammatory osteoclasts leading to increased ATP production, purine metabolism and elevated ...