is a naturally occuring mouse line that displays a phenotype of accelerated aging. While maintaining an inbred AKR/J line in the early 1970's, researchers at Kyoto University became aware that some of ...

To do so, they developed a transgenic mouse model carrying a slime mold endonuclease that ... However, ten months after the treatment, “we found a lot of aging phenotypes,” such as gray hair, muscle ...

Research Interests: Somatic Stem Cells and Aging, Genetic Mechanisms of Stem Cell Maintenance, Therapeutic Approaches to Tissue Rejuvenation, Mouse Models of Hair Graying, Melanocyte Stem Cells and ...

While mice do not typically develop gray hair as part of the aging process, the research team created a genetically modified mouse model to mimic the effects of early graying, approximating the ...