Nephrotoxicity, the major complication of long-term therapy with amphotericin B, is attributed to drug-induced renal vasoconstriction plus a direct toxic action on renal tubules. Hypokalemia and ...

Amphotericin B deoxycholate 0.6–1 mg/kg +/− flucytosine 25 mg/kg four times daily Echinocandin** *Anidulafungin 200 mg loading dose, then 100 mg/day; Caspofungin 70 mg loading dose ...

Hospitalized adults (≥18 years old) whose antifungal therapy was switched from amphotericin B deoxycholate to a lipid formulation of amphotericin B, caspofungin, or voriconazole were included.