TCR can be used to identify naturally tumor-reactive T cells, but little is known about the differences in the TCR repertoires of CD4+ and CD8+ TILs. Methods: TCR high-throughput sequencing was ...

Institute for Advanced Optics, Hunan Institute of Science and Technology, Yueyang, Hunan 414006, China School of Information Science & Technology, Hunan Institute of Science and Technology, Yueyang, ...

Eventually, such LAA-derived peptides are presented towards CD4 + helper and CD8 + cytotoxic T lymphocytes (CTLs). Peptide vaccination now consists of the inoculation of peptides, preferentially ...

IL-1 activity on both DCs and T cells can further shape the adaptive immune response with variable outcomes. IL-1 signaling in DCs promotes their ability to induce T cell activation, but also direct ...

AV-001 is under clinical development by Vasomune Therapeutics and currently in Phase I for Coronavirus Disease 2019 (COVID-19) Associated Acute Respiratory Distress Syndrome. According to GlobalData, ...

Based on this evidence, basic research into IC/BPS has shifted to target each subtype of IC/BPS. Today, experimental murine models of autoimmune cystitis are used for HIC research, whereas models ...

Objective: This study examined the correlation between immunodominance of the major egg antigen Sm-p40 234-246, a robust Th1/Th17 anti-egg CD4 T-cell response, and severe liver immunopathology in ...