However, in the late 1980’s, it was shown that macrophages have a unique ability to enzymatically metabolize Arginine to Nitric Oxide (NO, a gaseous non – specific killer molecule) or to Ornithine (a ...

L-arginine might therefore benefit RA therapy by reducing joint inflammation and also ameliorating bone destruction. References [1]Hannemann, Nicole, et al. “Transcription factor Fra-1 targets ...

Pegargiminase is a PEGylated therapeutic protein based on a microbial enzyme, arginine deiminase (ADI). It converts extracellular arginine into citrulline, thus blocking the external supply of ...

Arginine and ornithine are precursors of nitric oxide and polyamines, respectively. These metabolites intimately participate in permeability and adaptive responses of the gut. The liver possesses high ...

Transcriptomic features of aaRS-stimulated macrophages were examined using RNA-sequencing. Serum and synovial fluid (SF) aaRS levels in patients with RA were assessed using ELISA. Peptidyl arginine ...