In parallel to the clinical trials, the Imperial group made a number of seminal observations which gave a mechanism for the more beneficial effect of the β2AR blocker carvedilol. They showed that the ...

Two protocols for switching between carvedilol, a third-generation nonselective agent with vasodilation through α 1 blockade, and a β 1-selective agent (e.g., metoprolol, atenolol) are described ...

Although switching is usually safe and well tolerated, physician judgment concerning individual patient requirements must be maintained. The dose of the first- or second-generation β blocker that ...

When is the Elden Ring Nightreign beta? The Lands Between beckons us once more for a standalone co-op adventure that introduces a roguelike loop into FromSoftware’s formula. Playtests are the ...

An increased burden of premature atrial contractions (PACs) has long been considered a benign phenomenon. However, strong evidence of their involvement in the occurrence of atrial fibrillation (AF), ...

Cardiac fibrosis is a major and complex pathophysiological process that ultimately culminates in cardiac dysfunction and heart failure. This phenomenon includes not ...

45 The influence of rate-pressure product on resting flow and its correction for CFR determination should be considered. The third mechanism of microvascular dysfunction is inappropriate propensity to ...

Monster Hunter Wilds is hosting open beta test 2 in February, giving us what we assume is the final chance to play ahead of the launch later in the month. Like the open beta test held in October ...

When is the next Monster Hunter Wilds beta? The Monster Hunter Wilds open beta allows players to experience a limited portion of the game ahead of launch, including a character creator to put ...

Countries with commitments under the Kyoto Protocol to limit or reduce greenhouse gas emissions must meet their targets primarily through national measures. As an additional means of meeting these ...