Apoptosis is an essential characteristic of cancer and its dysregular promotes tumor growth, clonal evolution, and treatment resistance. B-cell lymphoma-2 (BCL-2) protein family members are key to the ...

The new use is the third for Kymriah (tisagenlecleucel) in the EU and offers patients with grade 1, 2 and 3A follicular lymphoma that has returned after two or more prior treatments a new ...

BH3 mimetics are small molecules that mimic BH3-only proteins by binding to and inhibiting the prosurvival members of the Bcl-2 family ... (the majority with follicular lymphoma) received ...

Bristol Myers Squibb today announced the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended approval of Breyanzi® (lisocabtagene maraleucel; ...

John Seymour, MBBS, FRACP, PhD, explains the mechanism of action of BCL-2 inhibitors like venetoclax. John Seymour, MBBS, FRACP, PhD, director of hematology at the Peter MacCallum Cancer Center and ...

Table 2. Distinction between atypical lymphoid ... Distinction between atypical lymphoid proliferations with follicular pattern and follicular lymphoma. Atypical lymphoid proliferations with ...

Sonrotoclax is under development for the treatment of relapsed and refractory multiple myeloma, B-cell malignancies such as nodal, extranodal, splenic marginal zone lymphoma, mantle cell lymphoma, ...

The addition of Monjuvi to standard-of-care therapy reduced the risk of disease progression, relapse, or death in patients with relapsed/refractory follicular lymphoma Compared to placebo, the ...

Introduction: Follicular lymphoma (FL) is a common type of non-Hodgkin lymphoma that is incurable but often follows an indolent course. While survival is improving thanks to advances in diagnosis, ...

Sonrotoclax is under development for the treatment of relapsed and refractory multiple myeloma, B-cell malignancies such as nodal, extranodal, splenic marginal zone lymphoma, mantle cell lymphoma, ...

David Hockenbery (Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis): "Bcl-2 is the oncogene located at the breakpoint of the chromosomal translocation t(14;18) ...

However, the Nintendo Switch 2 will not arrive in your mailbox for at least the next few months. While we have a better idea of what it looks like, we still have to rely on leaks and rumors for ...