All OPTs were successful. De-labelling allowed five additional patients (11% of those receiving antibiotics) to receive the preferred beta-lactam. Including patients who were subsequently assessed in ...

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β-Lactams are the most widely employed antibiotics in clinical settings due to their broad efficacy and low toxicity. However, since their first use in the 1940s, resistance to β-lactams has ...

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2022). Gram-negative bacteria present resistance profiles mediated by beta-lactamases, one of the major groups of enzymes that resist the antibiotic effect by hydrolyzing the amide bond of the ...

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