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生物通
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APOE4和久坐生活方式协同损害清醒小鼠视觉皮层的神经血管功能
本研究表明,APOE4 小鼠在视觉皮层存在神经血管功能障碍,在神经元活动增加时,其血管反应与神经元能量需求不匹配,且这种功能障碍在久坐小鼠中更为明显。体育活动能改善多数神经血管功能指标,对 APOE4 小鼠的作用尤为显著,可增加血管反应的频率和大小,改善神经血管耦合。然而,APOE4 ...
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