In a recent study, scientists have introduced an innovative imaging technique that provides an unparalleled view of the bone marrow’s intricate structure, focusing on leptin receptor-expressing (LepR+ ...

Traditional imaging techniques have struggled to capture these elusive cell populations and the ... with tissue fixation to preserve the bone's structure, followed by decalcification to remove ...

Described in a new paper in Cell Stem Cell, the bone marrow model and the demonstration of its large-scale production ... researchers tried combining these ingredients, but struggled to replicate the ...

Bone marrow plays a crucial role in maintaining hematopoietic stem cells and bone homeostasis. However, research has been hindered by a lack of effective markers and monoclonal antibodies to ...

Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

Researchers have developed a platform that emulates human bone marrow's native environment. This breakthrough addresses a critical need in medical science, as animal studies often fail to fully ...