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妊娠期自身抗体暴露影响MAR自闭症大鼠模型的早期大脑发育
本研究利用与临床相关的大鼠模型,深入探究妊娠期暴露于临床相关 MARA - AB 模式对出生后早期大脑基因表达和免疫信号分子的影响。在大鼠 PND2 时,其大脑神经发育过程与人类妊娠晚期相似,此时胎儿大脑在关键发育阶段易受外界因素影响,MARA - ABS 可通过胎盘进入胎儿体内,与靶蛋白相互作用,可能改变早期神经发育轨迹,影响细胞因子、趋化因子和生长因子等信号分子。
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