CCL2, a pivotal cytokine within the chemokine family, functions by binding to its receptor CCR2. The CCL2/CCR2 signaling pathway plays a crucial role in the development of fibrosis across multiple ...

Activation of MAPK pathway drives significant increases in CCL5 secretion by tumor cells, thereby impacting the abundance of Treg cells (71). Conversely, the CCL5/CCR5 axis can also activate the ...

Given the negative prognosis associated with high CCL5 serum levels in human patients and its diverse functions in chemokine and paracrine signaling (Aldinucci et al., 2020), we hypothesized that ...

STOP Leg Clots a national multicenter study to investigate if the addition of mechanical thrombosis inhibition via so-called intermittent pneumatic compression (IPC) during lower leg immobilization ...

Collectively, these results provide a novel molecular pathway, by which MCP-1/CCR2 signal transduction is linked to transcriptional gene regulation leading to apoptosis. Because MCP-1 and cell death ...