5B). MIP-1α specifically bound to CCR5-expressing cells and not to control cells expressing another chemokine receptor, CXCR4. The binding of radiolabeled MIP-1α to the CCR5-expressing cells was ...

We demonstrate here that cell surface expression of HSPG alone is insufficient for AAV infection, and that AAV also requires human fibroblast growth factor receptor 1 (FGFR1) as a co-receptor for ...

After the formation of conjugates, the CD4 receptor and CXCR4 or CCR5 co-receptors are recruited at the site of the cell–cell contact (96). Furthermore, intercellular transfer to CD4+ T cells of virus ...

She received a cord blood transplant to treat the AML, receiving stem cells carrying a genetic mutation (CCRΔ5/Δ32) which means they lack the CCR5 co-receptor used by HIV to get access to cells ...

A combination of methods, including a new method for tagging genes, demonstrates that the chemosensory co-receptors of Drosophila melanogaster (Orco, IR8a, IR25a, IR76b) are expressed widely and ...

stanford.edu Objectives While various monocyte chemokine systems are increased in expression in osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors ... CCR5, propagate ...

Before fusion of the HIV viral envelope and host cell membrane can occur, an HIV glycoprotein complex consisting of glycoproteins gp41 and gp120 must bind with the CD4 receptor on the membrane of ...

Impact of nonfunctional chemokine receptor alleles on HIV resistance & disease progression Homozygotes and heterozygotes for CCR5 d32, which are prevalent in European populations, exhibit a strong ...

We validated T-CAST by assessing off-target effects of two promiscuous TALENs designed to target the CCR5 and TRAC loci. Expression of these TALENs caused high ... MR, TIC, and TC wrote the manuscript ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900 USA 2Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical ...

What are the best co-op games? Games offer up magic in lots of different guises, but working with a friend to achieve a goal is, arguably, where they shine. So what are the titles that will pull ...