CRISPR-Cas9技术因其高效的基因编辑能力成为功能基因组学的重要工具。然而，传统CRISPR筛选在复杂的体内模型（in vivo）中常面临瓶颈效应与生物异质性的挑战，导致结果数据噪声大，难以精准 ...

神经免疫相关研究是科研的热门方向，在调研了一线科研工作者的需求后，我们联系并邀请到了浙江大学研究员侯宇作为讲者对近期一项研究进行分享，分享主题为CRISPR-Cas9 筛选揭示神经-免疫 ...

*仅供医学专业人士阅读参考我们知道，诱导免疫原性细胞死亡（ICD）是一种能改善癌症免疫治疗效果的临床药物应用策略。ICD可通过释放损伤相关分子模式（DAMPs），如钙网蛋白（CRT）、热休克蛋白（HSP）、三磷酸腺苷（ATP），以及高迁移率族蛋白B1 ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.

Get Instant Summarized Text (Gist) CRISPR nucleases, Cas9 and Cas12, have been engineered to evade immune detection, addressing a key challenge in CRISPR-based therapies. By identifying and ...

crRNA阳性对照套装：检测编辑体系正确性 crRNA阳性对照套装用于检测基因剪切体系的正确性，该套装包括阳性对照crRNA、正向引 CRISPR crRNA Library文库 锐博生物提供适用于大规模筛选的化学CRISPR ...

Then Crispr came along—the elegant enzymatic apparatus that allows delivery of DNA scissors to a specific target in the genome. In December 2023, the FDA approved the first Crispr-based therapy ...

CRISPR Therapeutics' stock decline is likely influenced by Editas Medicine's struggles, but CRISPR remains a distinct and stronger company with a promising long-term outlook. CRISPR's strategic ...

CRISPR Therapeutics AG is a gene editing company, which engages in the development of transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform.

本研究利用了小鼠体内以及体外的CRISPR-Cas9筛选系统，筛选了调节CD4+ T细胞分化的关键作用因子，揭示T细胞表达的神经递质受体（RAMP-CRLR）能够直接 ...