The balance between the activities of two families of enzymes: ACs and cyclic nucleotide PDE regulate the intracellular cAMP level and its spatiotemporal distribution. PDEs are intimately coupled to ...

PDE2 (phosphodiesterase 2) is upregulated in human heart failure. Cardiac PDE2‐transgenic mice are protected against contractile dysfunction and arrhythmias in heart failure but whether an acute ...

cAMP critically modulates the development of neuronal connectivity. It is involved in a wide range of cellular processes that require independent regulation. However, our understanding of how this ...

py-pde is a Python package for solving partial differential equations (PDEs). The package provides classes for grids on which scalar and tensor fields can be defined. The associated differential ...

Garrett Camp is a tech-oriented entrepreneur who co-founded Uber Gordon Scott has been an active investor and technical analyst or 20+ years. He is a Chartered Market Technician (CMT). Garrett ...

Siyabonga Masinda spoke about water stress in Makhanda, returning to agriculture and supporting family, local herbs and international politics.

The Camp Snap is a mish-mash between a disposable film camera and a modern digital camera, resulting in an all-digital but screen-free compact camera. The camera is full of retro charm many will love, ...

"For decades, we believed that an enzyme called phosphodiesterase was the critical factor in decreasing cAMP. We now refute that and say this transporter simply leaks it out." The finding has ...

"For decades, we believed that an enzyme called phosphodiesterase was the critical factor in decreasing cAMP. We now refute that and say this transporter simply leaks it out." The finding has ...

The cAMP determinations in duplicate wells were ... with 100 μM of the phosphodiesterase inhibitor RO-20-1724. Cells (50 μl membrane suspension containing 250,000 cells), added to triplicate ...