Maintaining treatment with CDK4/6 inhibitors significantly suppresses the growth of breast cancer cells, even after drug resistance has developed, according to new research.

Aneuploid cancer cells exhibit increased long-term sensitivity to SAC inhibitors ... levels and the sensitivity to SAC inhibitors goes beyond a mere association of a cell cycle marker and the response ...

Trilaciclib significantly reduced chemotherapy-induced myelosuppression in extensive-stage small cell lung cancer, which ...

The development of targeted therapies using tyrosine kinase inhibitors and immunotherapies has significantly improved the quality ... A search for the membership term “Lung Cancer, Cell Cycle, ...

Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been ...

Phosphoproteomics unveils the mode of action of clinical ATR inhibitors and explains their synergy with Gemcitabine in pancreatic cancer cells. Viability screening of 146 targeted drugs identified ATR ...

Two newly identified disease-causing genes, known as Bzw2 and Eif5a2, have been implicated in early prostate cancer ...

Therapeutic inhibition of KRASG12C and eventual resistance to these inhibitors are also known to drive RS and DNA damage through adaptive mechanisms that maintain addiction to high MAPK signaling.

Immunotherapy drugs work by priming the immune system to fight cancer cells. A few therapies based on this approach are currently being used or tested against lung cancers. They include immune ...

Neoadjuvant Keytruda for patients with deficient DNA mismatch repair colon cancer resulted in a pathological complete ...