There is evidence to indicate that full adrenergic blockade by carvedilol improves survival and cardiovascular outcome in patients with heart failure compared with metoprolol treatment ...

A number of comparative studies have been performed with metoprolol, a β 1-selective "second-generation" β blocker, and carvedilol, a nonselective and vasodilatative "third-generation" β blocker.

When directly comparing clinical effects of carvedilol and metoprolol, equipotential doses of both β blockers should be used. The target doses recommended in multicenter trials with survival ...