in response to cathepsin B release from damaged lysosomes or in response to reactive oxygen species (ROS) released from damaged mitochondria. NLRP3 inflammasome activation results in active caspase-1, ...

Each step was adjusted for multiple testing using Bonferroni correction. Results: Our analyses identified two proteins (Cathepsin B and ECHDC3) that met all the criteria to mediate the polygenic ...

Diabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD), which is characterized by a series of abnormal changes such as glomerulosclerosis, podocyte loss, renal tubular atrophy ...

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Key Laboratory of Organosilicon Chemistry and Materials Technology of the Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Materials, Chemistry and ...

NLRP1 inflammasome activity is regulated by the anti-apoptotic mitochondrial factors BCL-2 (B-cell lymphoma 2 ... associated hyperactive mutants of NLRP3 induces pyronecrosis.

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