Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77845, United States ...

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Therefore, development of new therapeutic strategies is awaited. The aim of this study is to demonstrate the efficacy of MOD06051, a novel CatC inhibitor, against MPO-AAV, using an MPO-AAV rat model ...

This first tissue-specific cathepsin was associated with pycnodysostosis, a genetic disorder observable as an osteopetrotic phenotype in cathepsin K-deficient mice. Cystatin C, an endogenous inhibitor ...

To further investigate the role of cathepsins in post-MI LV remodelling process, a non-selective cysteinyl cathepsin inhibitor E64d was administrated within the first 7 days of post-MI. Cardiac ...

particularly cathepsin K, and their extracellular inhibitor cystatin C in articular cartilage of transgenic Del1 mice which harbour a short deletion mutation in a type II collagen transgene and are ...

Altogether our study brings a new mechanistic detail in the NLRP3 inflammasome activation pathway by several activators. Moreover, it raises the importance of Cathepsin B and the interest to develop ...

Background Although cathepsin C (CTSC), a multifunctional molecule ... Furthermore, we found that TNF-α could activate CTSC expression in a concentration-dependent manner. Ralimetinib, an oral MAPK ...