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Background: The lysosome plays a vitally crucial role in tumor development and is a major participant in the cell death process, involving aberrant functional and structural changes. However, there ...

Targeted drugs hold great promise for the treatment of malignant tumors; however, there are several challenges for efficient evaluation of these drugs in preclinical and clinical studies.

急性胰腺炎（AP）起病急、并发症发生率高，是普通外科常见急症之一，如干预不及时，可向危重症转变，严重影响病人预后。目前临床上以支持治疗和手术为主要治疗方式，然而当前并无有效药物能够逆转AP发生发展。AP的发病机制包括胰蛋白酶原异常激活、病理性钙信号传 ...

1 The MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK Background Acute respiratory distress syndrome (ARDS) is an often fatal ...

Department of Chemistry and Biochemistry, Warren Center for Drug Discovery, The University of Notre Dame, 305 McCourtney Hall, Notre Dame, Indiana 46556, United States ...

The actin cytoskeleton is composed of a dynamic filament meshwork that builds the architecture of the cell to sustain its fundamental properties. This physical structure is characterized by a ...