This review provides an overview of TLR signaling pathways and their regulators and discusses how TLR signaling, directly and indirectly, regulates cell-mediated immunity. In addition, we also discuss ...

Although B cells ... cell-mediated processes that are involved in presenting antigen to B cells in vivo. You have full access to this article via your institution. As cells of the immune system ...

In the immune system, cAMP is a potent negative regulator of T cell receptor-mediated activation of effector T cells (Teff) acting through a proximal PKA/Csk/Lck pathway anchored via a scaffold ...

Cellular immunity ... cell responses. Mutations occurring in T cell epitope hotspots in the viral spike protein and in a highly conserved site in the viral nucleocapsid suggest that T cell ...

Triggering receptor expressed on myeloid cells 2 (TREM ... liver axis and innate immunity play a significant role in liver injury. Impaired intestinal permeability may promote liver inflammation due ...

1 Department of Medicine, Division of Gastroenterology & Hepatology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK 2 Wellcome Trust PhD Programme for Clinicians, Cambridge Institute ...

Contrary to prior data, this study shows that neither eosinophils nor STAT6-mediated IL-4/IL-13 signaling contribute ...

Your immune system includes your body's cells, tissues, and organs, which work together to fight off infections and diseases. But how much do you know about it? When you understand everything that ...

However, on the basis of existing data, it is plausible that naturally acquired immunity may be as good as the degree of vaccine-mediated immunity required by proposed mandates ... Looking forward, it ...

CARD9 is a fundamental signalling-molecule in Th17-responses and antifungal immunity; thereby positioning it at a compelling ... which environmental fungi trigger Dectin-1 on neutrophils through a ...

Most importantly, he found differential expression changes that always led to prosurvival adaptation of senescent cells mediated by BCL-XL, an anti-apoptotic protein that prevents the process of ...

The human immune system is like an army of specialized soldiers (immune cells) each with a unique role to play in fighting disease. In a new study published in Nature, led by scientists at the ...