The three main known genetic mutations in FH impact LDLR (most common), APOB (apolipoprotein B, about 10% of FH cases), or ...

wondered if inherited genetic variants — instead of mutations that happen in tumors — might give cancer cells wanderlust. Mei and colleagues found that a variant of the PCSK9 gene was ...

the Tavazoie lab dove into human genetics with large patient cohorts from multiple countries. A common variant of the PCSK9 gene immediately caught their attention. Present in the germlines of 70 ...

JE: Human genetic studies provide strong target validation for the role of PCSK9 in modulating LDL cholesterol (LDL-C) levels and the risk of coronary heart disease (CHD). In 2006, Cohen and co ...

Epigenome editing is an attractive alternative, as it modifies the chemical groups that decorate the DNA without changing the genetic sequence ... to silence the Pcsk9 gene, which produces ...

Both types are effective at managing cholesterol, but researchers have uncovered some surprising side effects. Weight Gain: ...

Traditionally, genetic studies have been conducted on populations ... He counters this objection by citing the example of PCSK9, a gene that codes for a protein that regulates cholesterol levels ...