absence of the melanin-forming enzyme, tyrosinase; absence or decrease of the melanin precursor, tyrosine; and finally, inhibition of the tyrosine–tyrosinase reaction by phenylalanine or related ...

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...