Not all genes are active at all times. DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression. This straightforward experiment demonstrated that it was ...

Senescence is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence can be induced by unrepaired DNA damage ...

One such defense is cellular senescence, a state where ... identified multiple mechanisms by which cancer cells suppress FBP1, including DNA methylation and protein degradation.

More information: Lishomwa C. Ndhlovu et al, Retro‐age: A unique epigenetic biomarker of aging captured by DNA methylation states of retroelements, Aging Cell (2024). DOI: 10.1111/acel.

A new research paper was published in Aging (Aging-US) on January 3, 2025, in Volume 17, Issue 1, titled "Characterization of DNA methylation clock algorithms applied to diverse tissue types." ...

The latest findings on the interaction between cell death and cellular senescence in cancer and their pathophysiological significance have been reviewed.

In the ever-evolving field of longevity and anti-aging research, chemical sciences are making significant strides, transforming longevity research. These advancements focus on developing chemical ...

which unwinds DNA and allows transcription to occur. When the researchers probed the specific pattern of histone methylation at human cryptic sites, they found that it matches the patterns discovered ...

Researchers analyze various aspects of gene regulation, among which are the three-dimensional structure of the genome and DNA methylation, which differ for different cell types and play significant ...

He is director of the UAB Cell Senescence Culture Facility ... but rather, modifications of DNA or its associated proteins and Dr. Tollefsbol's laboratory is interested in these processes as ...

Dunn, recently carried out a study exploring how DNA methylation, an epigenetic modification that entails the addition of a methyl group to the DNA, contributes to the well-documented relationship ...