Debeyelaan 25, P.O. Box 5800, Maastricht 6202 AZ, The Netherlands; suzanne.sallevelt{at}mumc.nl Background Severe, disease-causing germline mitochondrial (mt)DNA mutations are maternally inherited or ...

While the virus is generally found in wild birds and poses risk only to poultry, its spread to a new range of mammals may pave the way for new mutations that could increase its lethality. In 2024, the ...

In a family of 15 people in northern Italy, six developed late-onset Alzheimer’s disease – and when researchers ran genetic tests, all six had a rare mutation in a protein-coding gene known as ...

A GROUNDBREAKING study has uncovered a new class of DNA lesions that persist in human stem cells for months to years, contributing significantly to the mutation burden in somatic cells. Researchers ...

When Neandertals were first discovered nearly 170 years ago, the conceptual gap between their lineage and that of modern humans seemed vast. Initially scientists prejudicially believed that the ...

Researchers found that random genetic mutations drive predictable changes in DNA methylation, offering new insights into the relationship between mutation accumulation and epigenetic clocks. This ...

By comparing genetic mutations to epigenetic modifications, they found that mutations were predictably correlated with changes in DNA methylation, one type of epigenetic modification.