Researchers have previously tried sticking down one end of a DNA molecule to stretch it out, but found that the thermal fluctuations could still cause movement and blurring. "Stretching DNA refers ...

"Our experiments show that SMCs momentarily pull DNA from one side, and then switch direction to pull DNA from the opposite side. By doing so, they can pull DNA into a loop from both sides over time.

They next broke up the DNA from each cell type and isolated histones that bore specific modifications, using antibodies and beads to pull down the modified histone of interest and its associated ...