The primary goal of mouse mutagenesis programmes is to develop a fundamental research infrastructure for mammalian functional genomics and to produce human disease models. Many large-scale ...

“and we hope to combine our data with the Korean Animal Model Archive to help build a national genetic variation dataset.” In 2013, the KMPC joined the International Mouse Phenotyping ...

1.2.3 The mouse as a model prior to the recombinant DNA revolution With the demonstration in the mouse of genetic factors that impact upon cancer, millions upon millions of animals were used to ...

Researchers at Karolinska Institutet have uncovered new insights into the mechanisms underlying autism spectrum disorder (ASD ...

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50% in a mouse model of the fatal neurodegenerative ...

Collaborative research is driving the development of future treatments to ease symptoms of autism and epilepsy. The ...

trans-activating CRISPR RNA (crRNA:tracrRNA) and Cas9 protein and then to full-length synthetic sgRNA ribonucleoprotein (RNP) complexes. Applications of sgRNA in animal model generation and cell line ...

The CAST mouse is invaluable, as its genetic background avoids artificial receptor modifications, making it a more natural model for studying severe COVID-19. "CAST mice stand poised to transform ...