However, emergent somatic mutations driving metastasis have not been identified in tumour evolution sequencing. An article in Cell now describes a germline mutation in proprotein convertase ...

The pair had helped identify a still-unnamed disease, which they had tied to a particular gene and to a particular somatic mutation—a genetic change that had not been passed down from a parent and was ...

The PubMed database was searched from January 2018 to May 2024. Articles were selected for inclusion if they reported on patients with metastatic prostate cancer who received a germline or somatic ...

A germ-line mutation looks like a red ball in a sea of white balls—difficult, but not impossible, to spot; a somatic mutation is gray, and more easily blends in. “In genetics, it can be hard ...