First, the researchers confirmed the presence of major DNA repair pathway machinery in each of four brain regions: the cerebral cortex, the hippocampus, the cerebellum, and the striatum.

To demonstrate the applicability of Hi-Q brain organoids for drug screening, glioma invasion was modelled by fusing patient-derived glioma stem cells (GSCs) to Hi-Q brain organoids and used for a ...

In particular, reduced maturation of the cerebellum—a brain region that controls appetite—helped explain the link between genetic risk for high BMI and restrictive eating behaviors at age 23.