from the angle of intratumoral communication among individual components of the glioma microenvironment. For a long time, cancer has been perceived as a cell autonomous disease caused dominantly by ...

We have assessed the effect of modulated TGF-β secretion from FAT1-depleted tumor cells on in vitro migration and phenotype of monocyte-derived cell line. Our results indicate a potential role of FAT1 ...

This study presents a detailed examination of the tumor-associated macrophages (TAMs) landscape within the glioma tumor microenvironment (TME). We identify vital TAM subpopulation involved in tumor ...

An important mechanism that mediates this neural regulation of brain cancer is activity-dependent cleavage and secretion of the ... effective therapeutic strategies will need also to target elements ...

The laboratory has identified genetic drivers of malignant progression of glioma. The lab is also focused on understanding how the tumor microenvironment influences the growth of tumor cells. The ...

The Cancer Genome Atlas project (TCGA ... Understanding the interaction between the genetically distinct subpopulation of glioblastoma cells and their microenvironment has yielded novel therapeutic ...

Glioblastoma is the most common kind ... The tumor cells are too varied, and the microenvironment is too tumor-friendly.

compared with higher-grade tumors, so they often have better outcomes. Low-grade gliomas are tumors that start in the glial cells in the brain, which support neuron function. Gliomas are ...