A study by DKFZ researchers shows that inhibiting the enzyme aldolase A in glycolysis traps energy in liver cancer cells, ...

Glycolysis is an important sugar degradation pathway that cancer cells in particular depend on. Scientists at the German Cancer Research Center (DKFZ) have now shown that liver cancer cells in mice ...

It utilizes lactate as the modification precursor, which is an end product of glycolysis while functioning as a signaling molecule in cells. Unlike previous reviews focused primarily on eukaryotes, ...

Department of Physiology and Pathophysiology (Y.T., Y.J., L.F., H.L., Y.L., J. Zhu., W.P., J. Zhou), School of Basic Medical Sciences, Peking University, Beijing ...

Leucine, isoleucine, valine and tyrosine were associated with sex and obesity [99] 263 nonobese subjects IR was associated with BCAA, aromatic chain amino acids, glycolysis metabolites ...

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education; Shaanxi Key Laboratory for Advanced Energy Devices; Shaanxi Engineering Lab for Advanced Energy Technology; ...

Tumor endothelial cells (ECs) have high glycolytic metabolism, shunting intermediates to nucleotide synthesis. Blocking of the glycolysis activator PFKFB3 in EC cells does not affect tumor growth.

This valuable study tackles the well-established overflow metabolism issue by applying a coarse-grained metabolic flux model to predict how individual cells execute various energy strategies, such as ...