Another noteworthy point is its impact on AMPK, sirtuin, and the PGC-1a pathway. AMPK is a cellular energy sensor with an essential role in fat, glucose, protein metabolism, and mitochondrial ...

The cause of the metabolic/mitochondrial remodeling in cancer is multifactorial, but several key molecules and transcription factors involved in metabolism and carcinogenesis are directly involved, ...

In recognising this UK Sport’s approach to funding reflects that journey and works on the basis of an athlete pathway with three clear and distinct levels that make up the World Class Pathway. The two ...

More than three years after the Pathways Alliance oilsands group first announced plans for a proposed $16.5-billion carbon capture network in northern Alberta, the consortium still hasn’t given ...

No county player made the cut for its 2024 Class 1A, 3A and 5A teams. Its Class 2A, 4A and 6A all-stars will be released Saturday. However, District 10 wasn't without representatives among Friday ...

In summary, our findings indicate that the TIPE/PKM2/HIF-1α signaling pathway plays a pivotal role in promoting cancer stem cell properties by facilitating the glycolysis, which would provide a ...

TIPE causes dimerization of PKM2, as well as translocation of PKM2 to the nucleus, thereby activating HIF-1alpha. TIPE promotes the phosphorylation of S37 on PKM2 ... showing a clear role for HIF1a in ...

A pair of high-powered rushing attacks will be on display when the Tarboro Vikings take on Corvian Community for the NCHSAA 1A championship Saturday at Carter-Finley Stadium in Raleigh.