Like for HIV, lymphopenia and drastic reduction of CD4+ T cell counts in COVID-19 patients have been linked with poor clinical outcome. As CD4+ T cells play a critical role in orchestrating responses ...

HPV is responsible for more than 95% of cervical cancer cases in South Africa. If a high-risk HPV infection persists, it can ...

In this study, we investigated T cell homeostasis and telomeric DNA damage and repair machineries in cART-controlled HIV patients at risk for inflammaging. We found a significant depletion of CD4 T ...

衰老对免疫系统的多重影响，不仅改变了其组成结构，还可能提升感染、恶性肿瘤及炎症性疾病的风险。随着全球60岁以上人口的显著增长，衰老对免疫相关疾病的影响愈发显著。在免疫系统中，与年龄相关的显著变化包括幼稚与记忆T细胞比例的改变，特别是衰老T细胞如IL- ...

随着创新药物的发展和抗逆转录病毒治疗的广泛应用，尤其是鸡尾酒疗法的不断优化，HIV感染者的预期寿命逐步延长。一项对20多万北美和欧洲成年HIV感染者的研究结果表明，CD4+T细胞（HIV病毒主要攻击的人体细胞）计数和年龄对预期寿命的影响最大 [2]— ...

首个专门针对清除潜伏HIV-1细胞的T细胞受体（TCR）疗法已经通过了初步临床试验。这种双特异性免疫疗法可以靶向并清除那些长期携带HIV的CD4+细胞，也就是所谓的“病毒储存库”。

S3). Immunohistochemical analysis showed a dense lymphocytic infiltration of the lamina propria positive for T-cell receptor (TCR) α, CD3, CD4, and granzyme B but which did not express TRBC1 ...

A key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T cell. Dysregulated CD4 T cells have been implicated in autoimmune liver disease ...

This man, an electrical engineer and father of two, has been diagnosed with both HIV and lymphoma. Today, nearly three months ...

In this cross-sectional study, researchers explored immune activation as a possible mechanism for this seemingly paradoxical response to HIV infection. CD4-cell counts and T-cell activation levels ...

10, 2024 — A newer vaccine against hepatitis B virus was clearly superior to an older vaccine type in inducing a protective antibody response among people living with HIV who didn't respond to prior ...