Antiretroviral drugs that prevent HIV from entering host cells by blocking the fusion of the viral envelope with the cell membrane. gp41: A glycoprotein on the surface of HIV-1 that is essential ...

Viruses such as HIV-1 and poliovirus can enter and exit ... Figure 5: Conformational changes of viral fusion proteins leading to membrane fusion. A number of models have been suggested for fusion ...

"Since viruses cannot synthesize lipids, HIV 'steals' lipids from the plasma membrane of host cells," explains Toshihide ...

Coreceptors are responsible for a crucial step between Env binding to the receptor CD4 and membrane fusion mediated by the gp41 fusion peptide. Determinants of HIV cell tropism & chemokine ...

2009;66(8):715-726. Mechanism of action of maraviroc. Before fusion of the HIV viral envelope and host cell membrane can occur, an HIV glycoprotein complex consisting of glycoproteins gp41 and ...

A new study highlighting the importance of a large protein complex called the exocyst in cell growth, division and ...

However, the HIV-1 envelope protein is highly ... that reveal key pieces of itself critical for viral fusion that were buried deep in the membrane. Consequently, the antibody is then able to ...

This causes a change in conformation that inserts fusion peptides into the cellular membrane. Width of image is approximately 100 nm. This image forms part of a series of illustrations which capture ...