As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

jpi{at}soton.ac.uk BACKGROUND Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix ...

The liver is composed of parenchymal cells (hepatocytes) and non-parenchymal cells, with liver non-parenchymal cells mainly encompassing LSEC, hepatic stellate cells, Kupffer cells, and immune cells.

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

“These viruses can cause cell death, and chronic infections can lead to scarring, or fibrosis,” says Sudha Kodali, MD, a hepatologist in Sugar Land, Texas, and a volunteer for the American ...

After hours: February 7 at 6:42:18 PM EST Loading Chart for MRKR ...

Jan. 23, 2025 — There's a downside to being a powerful alpha male -- at least if you're a baboon. Studies show that despite their high rank, the No. 1 males in baboon society are also some of ...

Cell biology is the discipline of biological sciences that studies the structure, physiology, growth, reproduction and death of cells. Research in cell biology uses microscopic and molecular tools ...

One way to differentiate them is to detect specific molecules on these cells that act as markers. Some aspects of the disease can be readily seen by studying individual cells and their appearance, ...

Background: Programmed death 1 (PD-1) and the ligand of PD-1 (PD-L1) are central targets for immune-checkpoint therapy (ICT) blocking immune evasion-related pathways elicited by tumor cells. A number ...

Cell signalling is the mechanism by which stimuli are transmitted via a signalling cascade to effector molecules that orchestrate the appropriate response. Types of cell signalling pathways ...