Interferon gamma-1b is under clinical development by Amgen and currently in Phase II for Myelodysplastic Syndrome.

Interferon gamma (IFN-γ) is a cytokine that induces a series of immune responses against viruses and tumors. The pro-apoptotic, anti-tumor and anti-proliferative actions of the cells are ...

In further analyses in mice and human blood cells ... A likely culprit causing Sjögren's disease symptoms in mice: interferon gamma. "It came down to a defect in regulatory T cells and an ...

IFI16 facilitates the inflammatory endothelial pathophenotypes observed among individuals with PAH, according to new research ...

HIF1α identified as key regulator that induces cancer-killing ability of hypoxic T cells, playing a role in ICB resistance.

how HIF1α in T cells is key for induction of interferon gamma, or IFN-γ, in that hypoxic environment. The cytokine IFN-γ is known to be essential to induce the tumor-killing capacity of T cells.

In a study published in Nature Communications, Lewis Zhichang Shi, M.D., Ph.D., and University of Alabama at Birmingham colleagues show, for the first time, how HIF1α in T cells is key for induction ...

In further analyses in mice and human blood cells ... A likely culprit causing Sjögren's disease symptoms in mice: interferon gamma. “It came down to a defect in regulatory T cells and an ...