Science Immunology. 2024 saw the completion of several cellular-resolution brain maps, including the entire fly brain and a comprehensive connections map of a cubic centimeter of human brain. 2025 ...

SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in microglia.

While this option may be less expensive and seems convenient, it’s best to consult a doctor about dosage if you use it, says Joshua J. Neumiller, CDCES, PharmD, the president elect of ...

When you have diabetes, insulin is vital to help keep your blood sugar levels in check. If you have type 1 diabetes, you must inject insulin daily. Those with type 2 diabetes may also require ...

The most-read gene therapy articles included topics on FDA approvals, chimeric antigen receptor T-cell therapies, the cost-effectiveness of gene therapies, as well as other findings. Real-world ...

This study provides compelling evidence for functional subpopulations of β-cells responsible for Ca2+ signal initiation and maintenance ... help decode mechanistic underpinnings of islet calcium ...

Polycystic ovary syndrome (PCOS) can put you at risk for insulin resistance. Watch for symptoms of insulin resistance that are common for females with PCOS. These include cravings and frequent ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Impaired insulin receptor signaling is ...

Figure 1. Structures of the insulin/insulin-like growth factor (IGF) system. Insulin, IGF1, and IGF2 and their relatively high-affinity receptors, insulin receptor, IGF1 receptor, and IGF2 receptor, ...

A single-center pilot study at the Veterans Affairs Hospital/University of Washington in Seattle reported improved verbal memory retention and attention after a three-week test of 20 international ...

He, H.J., Cen, X.H., Liang, Y.J., Zhong, J.M., Deng, J.H. and Jiang, Y.J. (2025) Progress in the Regulation of Lipid Metabolism by the Orphan Nuclear Receptor Nur77. Journal of Biosciences and ...