Insulin receptor substrate (IRS)-1 is a multitask protein that interacts with many other proteins. IRS-1 is mitogenic, inhibits differentiation, protects from apoptosis and regulates cell (and ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Impaired insulin receptor signaling is ...

When you have diabetes, insulin is vital to help keep your blood sugar levels in check. If you have type 1 diabetes, you must inject insulin daily. Those with type 2 diabetes may also require ...

Endothelial dysfunction is one manifestation of the many changes induced in the arterial wall by the metabolic abnormalities accompanying diabetes and insulin resistance. In type 1 diabetes ...

Figure 1. Structures of the insulin/insulin-like growth factor (IGF) system. Insulin, IGF1, and IGF2 and their relatively high-affinity receptors, insulin receptor, IGF1 receptor, and IGF2 receptor, ...

While this option may be less expensive and seems convenient, it’s best to consult a doctor about dosage if you use it, says Joshua J. Neumiller, CDCES, PharmD, the president elect of ...

Insulin is vital to control blood sugar in patients with type 1 diabetes, and is used by some patients with the more common type 2 diabetes. Minnesota's case began in 2018 under Ellison's ...

Three people with type 1 diabetes who received Vertex Pharma’s islet cell therapy VX-880 have been able to come off insulin altogether within a year, raising the prospect of a life without ...

A single-center pilot study at the Veterans Affairs Hospital/University of Washington in Seattle reported improved verbal memory retention and attention after a three-week test of 20 international ...

Doctors also prescribe it off label to manage prediabetes, type 1 diabetes, and other conditions. Metformin for insulin resistance Metformin is the only biguanide, and its brand-name versions ...

Dr Anne Peters discusses how to safely prescribe SGLT2 inhibitors in patients with type 1 diabetes to prevent diabetic ketoacidosis.