such as serine phosphorylation of insulin-receptor substrate proteins. These modifications resemble the events that occur during conditions of obesity, insulin resistance and type 2 diabetes.

A family of agonist drugs for peroxisome proliferator–activated receptor ... of PPAR-γ Ser273 phosphorylation could provide a new class of therapeutically useful insulin sensitizers.

the receptor undergoes autophosphorylation and becomes activated, leading to the downstream phosphorylation of insulin receptor substrate proteins. One of the biggest factors contributing to a ...