Impaired insulin receptor signaling is strongly linked to obesity-related metabolic conditions like ... TRIM family member TRIM32 to insulin resistance and related metabolic disorders. Here, our ...

which sustains cell survival and insulin sensitivity. Neuregulin, a Members of the Epidermal Growth Factor Family NRG is released by cells of endothelial, mesenchymal, and neuronal origin, while ErbB ...

Primary outcomes are cognitive function, cerebral blood flow, and brain glucose uptake. Other endpoints include Alzheimer’s-related blood biomarkers Aβ42/Aβ40 ratio, pTau181 and 231, NfL and GFAP, and ...

Increased serotonin signaling reduced sucrose appetite similar to a blocked or activated insulin receptor function. The reduction in sucrose appetite could be due to two different mechanisms. One ...

In a recent study published in the journal NPJ Metabolic Health and Disease, researchers hypothesize that the degradation of endogenously secreted insulin (as opposed to the commonly believed ...

Scientists discover how the Fas-p53 pathway ... Receptor (FAS) in regulating Tumor Protein p53 (p53) expression in adipocytes and its impact on energy metabolism, body weight gain, and insulin ...

One possibility is that in an attempt to overcome the inhibition within the metabolic insulin-signaling pathway, hyperinsulinemia may continue to stimulate the mitogenic insulin-signaling pathway ...

The hormone insulin, administered via a nasal spray, is being investigated as a treatment for Alzheimer’s disease. While insulin is best known for its role in regulating blood sugar, it also is ...