Tyrosine (Tyr) phosphorylation of p27 by Abl and Src family kinases reduces p27–CDK2 inhibition and transforms p27 from inhibitor to substrate of cyclin–CDK2 complexes. p27 phosphorylation at ...

A substantial and persuasive body of data now exists that supports the view that integrin alpha V beta 3 plays a critical part in activated macrophage dependent inflammation, osteoclast development, ...

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Angiogenesis inhibitors can be divided in 2 main groups according to their mechanism of action [3]: those that act directly on microvascular endothelial cells recruited by the tumor, such as ...

One of the most recent agents to enter phase 1 clinical trials, combretastatin A-4 phosphate (CA4P), represents a new class of antiangiogenic compounds that act by inducing apoptosis in target ...

Aromatase is an enzyme that converts testosterone to estradiol, a type of estrogen. One study found that taking an estrogen blocker called an aromatase inhibitor while on testosterone therapy reduced ...

2) Inhibitors of HDACs (HDACi) and identification of small molecule targeting BCL-3 leads to arrest in the cell cycle and effectively blocks proliferation and tumor growth. 3) Antibodies including ...