Different classes of integrin inhibitors are shown, mAb, monoclonal antibody ... Preclinical evidence in melanoma demonstrated its ability to induce anoikis and suppress metastasis in human melanoma ...

and non-integrin families (reviewed in Mecham9). However, little data is available on the alterations of the ECM receptors in HCC, and their role in vascular invasion and metastasis. We examined the ...

In this review, we summarize TAM ontogeny and polarization, and then explore how TAMs enhance tumor cell migration through the TME, thus facilitating metastasis. We also discuss how chemotherapy and ...

A substantial and persuasive body of data now exists that supports the view that integrin alpha V beta 3 plays a critical part in activated macrophage dependent inflammation, osteoclast development, ...

Lung cancer liver metastases are tumors that form in the liver from cancer cells that have broken away from the primary cancer and spread through the blood or lymphatic system. The liver is a common ...

Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including ...

Metastatic breast cancer affects people in many ways. The symptoms experienced by each person will vary based on the parts of the body that are affected. Some symptoms are a result of the cancer, and ...

The company also develops RAD 302, an avß6-integrin targeting agent for the treatment of multiple cancer types; RAD 101 and RAD 102 for brain metastases; RAD 402 to treat advanced prostate cancer ...

Cells navigating in complex microenvironments frequently encounter narrow spaces that physically challenge migration.

The heterogeneity of brain metastases highlights the differences from their primary source of origin and contributes to therapeutic resistance. Before colonising the brain, tumour cells acquire ...